These data suggest that the susceptibility to develop PTSD‐like phenotypes observed in 3‐month‐old Fmn2−/− mice is not accompanied by massive changes in gene expression, while memory impairment in 8‐month‐old Fmn2−/− mice correlates with substantial deregulation of transcriptome plasticity. This evidence concerns the gene FMN2 and post-traumatic stress disorder.