NFU1 and early-onset generalized limb-onset dystonia: Because EOTD appears to be a proteostasis disorder (Liang et al., 2014; Nery et al., 2011), and genes associated with metal-induced diseases are being considered as therapeutic targets (Flynn et al., 1991; Wong et al., 1999; Lodi et al., 2006; Schneider et al., 2012; Rouault, 2013; Jomova and Valko, 2011), NFU1 is another EOTD modifier candidate to be studied in future efforts.