In AD patients, CSF sTREM2 was not associated with changes in CSF Aβ42 [86, 202, 314, 316] but positively correlated with CSF biomarkers total tau [86, 202] and phosphorylated tau [202, 314, 316], including in cross-sectional cohorts with dominantly inherited AD [202]. This evidence concerns the gene MAPT and Alzheimer disease.