TREM2 is also upregulated in numerous other inflammation-related contexts, including sepsis [180], rheumatoid arthritis [181], corneal infection [182], macular degeneration [117], glioma [183], oral [184], esophaegeal [185], and liver [186] cancers, following prosthetic joint implants [187], osteoporosis [188], colonic mucosal injury [189], colitis [190], gastrointestinal mucositis [191] and muscular sarcoidosis [192]. Here, TREM2 is linked to central nervous system cancer.