However, this debate was largely settled in favor of the former when TREM2 variants were found to be significantly associated with risk for AD and other NDDs, and to form a genetic basis of polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy (PLOSL, also known as Nasu-Hakola disease). The gene discussed is TREM2; the disease is Nasu-Hakola disease.