Less work has been done in tau models of AD, but overexpressing TREM2 under the CD11b promoter in the P301S tau model of AD resulted in reduced hyperphosphorylated tau levels, coordinate with a decrease in activation of two of the known tau kinases, cyclin dependent kinase 5 (CDK5) and GSK3β [295]. The gene discussed is TREM2; the disease is Alzheimer disease.