Stress exposure of Pink1−/− primary neuron-rich cultures leads to the significant expression dysregulation of the abnormal DNA/RNA sensor Ifit3 and the iron-sulfur-cluster detector Rsad2, confirmed in Pink1-KO+A53T-SNCA double mutant brain, in human neuroblastoma cells, in Pink1−/− MEFs, and in PARK6 patient skin fibroblasts. Here, RSAD2 is linked to neuroblastoma.