SQSTM1 and Parkinson disease: The regional comparison in Table 1 made it evident that PINK1-deficiency-mediated downregulations of stress-response factors dominate in the PD-resistant cerebellar tissue, while the same factors show converse progressive upregulation in the PD-affected midbrain/brainstem tissue, e.g., Keap1, Mbtps1, Rad23a, Sec61a1, Hif1a, Pi4k2a, the autophagy factors Map1lc3b and Sqstm1. Further opposing regulations occurred for the ubiquitin-binding factor Tollip, which regulates Toll-like receptor signaling as well as the autophagic clearance of ubiquitin conjugates and protein aggregates [63].