LRRK2 and motor neuron disorder: In order to provide a time-correlation and comparison with autophagy factors that are also regulated by starvation, the curves for LRRK2 and SQSTM1 are shown as well (Fig. 3k–m), given that LRRK2 is a positive regulator of inflammation and autophagy, with mutations that trigger autosomal dominant Parkinson’s disease; SQSTM1 (sequestosome 1 = p62) was studied as an adaptor between the autophagy machinery and ubiquitinated cargo, whose mutation cause neurodegenerative disorders such as motor neuron disease.