Neuroblastoma cells responded by massive inductions of RSAD2, DDX58, IFIT3, and IFIT1, moderate induction of IRF3, and a downregulation of PINK1. The additional knockdown of PINK1 significantly blunted the upregulations of RSAD2 and DDX58 in SH-SY5Y cells. This evidence concerns the gene IRF3 and neuroblastoma.