In order to provide a time-correlation and comparison with autophagy factors that are also regulated by starvation, the curves for LRRK2 and SQSTM1 are shown as well (Fig. 3k–m), given that LRRK2 is a positive regulator of inflammation and autophagy, with mutations that trigger autosomal dominant Parkinson’s disease; SQSTM1 (sequestosome 1 = p62) was studied as an adaptor between the autophagy machinery and ubiquitinated cargo, whose mutation cause neurodegenerative disorders such as motor neuron disease. This evidence concerns the gene SQSTM1 and motor neuron disorder.