In a recent analysis of RTK-wild type GIST from the NIH Pediatric and WT GIST Clinic, Boikos et al. reported a median age of 15 y and a female predominance of 95% for patients with epimutant SDHC GIST, while the SDHX mutant GIST patient demographic was slightly older with less of a female predominance (median age of 23, 62% female) [50]. Here, SDHC is linked to gastrointestinal stromal tumor.