IDH2 and cancer: For a first assessment of the data, we examined the “cytokine-cytokine receptor interaction” subsection of the “pathways in cancer” expression network from KEGG (Fig. 2a), showing methylation of CpG sites that exhibit a standard deviation of more than 0.2 across all 165 samples, and grouping the data by IDH mutation status, i.e. wild-type, mutant, or unknown.