Cytokine production in vitro - Treatment with CXCL10 (100 ng/mL) in macrophages infected by L. infantum inhibited IL-4 production (significant at 24 h post-infection; p < 0.01) and IL-10 (p < 0.001) in two time periods (Fig. 3A-B). The gene discussed is CXCL10; the disease is infection.