IFNG and tuberculosis: The IL-12/STAT-1/IFN-γ axis is important for the control of Mtb, but robust induction of IFN-γ alone does not correlate with enhanced protection against developing TB disease in a variety of vaccine trials [6, 7], and there is mounting evidence for IFN-γ independent and Th17-mediated mechanisms of Mtb control [9, 52, 53].