Up-regulation of clusterin has been reported in response to pathological conditions, such as Alzheimer’s and Pick’s diseases[33–36], scrapie[37], spinal cord injury [38], axotomy [39], retinal ischemia [40], diabetic retinopathy [41] and retinal degeneration (RD) [42–46] including light-induced retinal degeneration [47–49] and RP [26, 50]. The gene discussed is CLU; the disease is diabetic retinopathy.