In a previous publication describing the effects of targeted deletion of AC6, which reduced LV cAMP generating capacity to a similar degree as does AC6mut expression, we found that limiting cAMP production did not prevent isoproterenol-induced cardiomyopathy, indicating that the pathogenesis of cardiomyopathy does not require sustained increases in cardiac cAMP levels. This evidence concerns the gene ADCY6 and cardiomyopathy.