MSH2 and lymphoma: The contribution of MSH2-/- LSK cells to hematopoiesis was comparable to WT LSK cells at 8 and 12 weeks post transplantation (Fig 2B), and the recipients developed T-lymphomas 16–30 weeks post transplantation (Fig 1B), suggesting that the hematopoietic reconstitution function of MSH2-/- HSCs is intact, and lymphoma initiating cells evolved from the HSC/progenitor cells after hematopoietic reconstitution.