FZD4 and Familial prostate cancer: Also, mRNA levels of Wnt pathway-related genes such as ligand WNT16 (hematopoietic stem cell [16]/prostate cancer resistance-related [17], 13.5-fold), receptors FZD2 (regulator of epithelial-mesenchymal transition (EMT)/colon cancer metastasis [18], 2.98-fold), FZD4 (glioma stemness [19], 3.9-fold) and transcription factor TCF7L2 (stem cell differentiation [20], 3.55-fold) were significantly downregulated (Table 1).