APOE and Alzheimer disease: Anotherwell-documented molecular marker for both the early-onset (Corder et al., 1993) and sporadic (Brouwers et al., 2008) AD is apolymorphism in the Apolipoprotein E (APOE) gene on chromosome 19.Association of the APOE ε4 allele with AD has been demonstrated inethnically different populations (Lehtimaki etal., 1995; Shimada etal., 1997; Tang etal., 1998; Panza etal., 1999; de-Andrade etal., 2000; Kim etal., 2001; Korovaitseva etal., 2001; Chen etal., 2003).