Consistent with the phenotypes observed in cancer cell lines, shRNA-induced FXR1 downregulation significantly inhibited cell proliferation only in the TP53 and FXR2 double knockout clones (Figure 2B) and had no effect on the TP53 single KO (Figure 2C) or FXR2 single KO (Figure 2D) clones. Here, TP53 is linked to cancer.