MMP‐13 cleaves the Ln‐5 fragments Ln‐5γ2ʹ and Ln‐5γ2x into smaller fragments, which prevents the transfer of the EGFR molecular signal into the cell, preventing the signal from inducing the rearrangement of the actin cytoskeleton and affecting the vascular phenotype of aggressive tumour cells. Here, EGFR is linked to neoplasm.