In this study, we firstly examined the level of miR‐30a in the experimental hepatic fibrosis models in vitro and in vivo, which showed that miR‐30a was down‐regulated in activated HSCs and exosomes secreted from cultured LX‐2 cells (LX‐2‐exosomes) induced by TGF‐β1, and in fibrotic liver tissues. This evidence concerns the gene TGFB1 and Hepatic fibrosis.