VMP1/MIR21methylation did not correlate with a known MS risk variant inVMP1 or smoking but displayed a significant negativecorrelation with age and the levels of mature miR-21 in CD4+ T cells.Accordingly, RR-MS displayed lower levels of miR-21 compared to SP-MS, whichmight reflect differences in age between the groups, and healthy individualsand a significant enrichment of up-regulated miR-21 target genes. The gene discussed is VMP1; the disease is myeloid sarcoma.