Approximately 1.5–2% of the individuals in this population carry one of two well-described founder variants: c.536A>G (p.Tyr179Cys) in exon 7 and c.1187G>A (p.Gly396Asp).40–42 It is known that MUTYH heterozygotes have an increased risk for colorectal cancer, and medical management and surveillance protocols have been developed.4 Colonoscopy every 5 years is recommended beginning at age 40 or 10 years earlier than the youngest age at diagnosis in an affected first-degree relative. This evidence concerns the gene MUTYH and colorectal cancer.