BRCA2 and breast carcinoma: Breast cancer is a multifactorial disease caused by a combination of environmental and genetic factors.1 In an estimated 10% of breast cancers, the genetic factor is contributed primarily by mutations in a single gene.2 Testing for BRCA1 and BRCA2 (BRCA1/2) has been available for more than two decades, and multiple professional organizations have developed guidelines for testing individuals based on suggestive personal or family history.3–7