ABCC4 and colorectal carcinoma: In summary, we provide evidences to support the conclusion that a polymorphism rs3742106 in the 3′-UTR of ABCC4 through altering the binding of miR-3190-5p to ABCC4 mRNA leads to disrupted expression of ABCC4, intracellular concentration of 5-FU, and individual response to 5-FU and capecitabine chemotherapy in CRC.