Further, we found that AKT1 inhibition induced phosphorylation of myristoylated alanine-rich protein kinase C substrate (MARCKS) and elevation of LAMC2 protein in the KRAS or EGFR mutant NSCLC cell lines, but not in those with wild type KRAS and EGFR. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.