TERT and osteosarcoma: To investigate the impact of TERT expression on cisplatin-induced apoptosis, osteosarcoma cells were stably transfected and separated into four groups, specifically, TERT-wildtype (TERT overexpressing cells), catalytically-inactive TERT (TERT overexpression cells with inactive telomerase reverse transcriptase), TERT-siRNA and negative control (mock-transfected cells).