BCL2 and follicular lymphoma: Of interest, the 76 SNVs are distributed across promoter regions of three genes (BCL6, BCL2, and HIST1H2BM; Fig. 2 and Supplementary Figure 1), where only 2 SNVs are near HIST1H2BM but 34 SNVs locate at a main regulatory mutation block (~500 bp; Fig. 2a) of BCL6 and the other 40 SNVs spread to two main regulatory mutation blocks (~350 bp; Fig. 2b) of BCL2. The two main regulatory mutation blocks of BCL2 are positioned in two known promoter regions of BCL2, which function differently between the normal germinal center cells and follicular lymphoma cells43.