Of interest, the 76 SNVs are distributed across promoter regions of three genes (BCL6, BCL2, and HIST1H2BM; Fig. 2 and Supplementary Figure 1), where only 2 SNVs are near HIST1H2BM but 34 SNVs locate at a main regulatory mutation block (~500 bp; Fig. 2a) of BCL6 and the other 40 SNVs spread to two main regulatory mutation blocks (~350 bp; Fig. 2b) of BCL2. The two main regulatory mutation blocks of BCL2 are positioned in two known promoter regions of BCL2, which function differently between the normal germinal center cells and follicular lymphoma cells43. Here, BCL6 is linked to follicular lymphoma.