ESR1 and breast carcinoma: We previously reported that MCF7 (estrogen receptor positive (ER+)) and MDA-MB-231 (triple negative) breast cancer cell lines (among other tumor types) are capable of dividing asymmetrically to form quiescent, AKT1low cancer cells (QCCs) in response to decreased integrin-β1 (ITGB1) signaling from the microenvironment both in vitro and in vivo [10, 11].