NR1H3 and hyperinsulinism: The related experiments have confirmed that in transgenic mice, ob/ob mice (the insulin resistance and hyperinsulinemia caused by leptin deficiency), mice and rats on diets containing higher cholesterol, other hyperlipidemia animals models, and patients with high blood lipids, the expressions of SREBP-1c and its lipid synthesis-regulated target genes in the livers, including FAS and ACC expression, were increased several times, resulting in a large number of TG deposition [52–56], and the gene expression of SREBP-1c is regulated by the nuclear liver X-activated receptor-α (LXRα).