NR1H3 and hyperlipidemia: Consistent with these findings, our results indicated that the expressions of LXRα, SREBP-1 and its target genes, and ACC and FAS, were significantly increased in the liver tissues of hyperlipidemia mice on the high-fat diet for 4 weeks, while the administration of SCL could down-regulate the expression of LXRα/SREBP-1c signal, and then reduce the expression of FAS and ACC, thereby reducing the production of TG and fatty acid and the lipid accumulation in the liver.