We performed pooled analyses with the available data on the pattern of E-cad expression in different molecular subtypes of invasive non-lobular breast cancers, and the results show significant difference in E-cad expression between the molecular subtypes of this disease (P < 0.010 in all cases between four molecular subtypes (4 studies), three molecular subtypes (7 studies), or two molecular subtypes (12 studies)) (Table 5). The gene discussed is CDH1; the disease is breast cancer.