The results of the present study show that the number of lymphocytes and eosinophils in BALF and the levels of IL-4, IL-5 and IgE in serum significantly increased in the OVA-induced asthma model rat, while the extracts of HE and FLL, budesonide and the combination of the extracts of HE and FLL with budesonide significantly decreased the levels of IL-4, IL-5 and IgE in serum and the number of eosinophils in BALF. This evidence concerns the gene IGHE and asthma.