Moreover, the expression of involucrin mRNA and protein was increased by treatment with erlotinib (Fig. 3c and Additional file 3 Figure S3B) or cetuximab (Fig. 3d and Additional file 3 Figure S3C) in all epithelial-like ESCC cells but not mesenchymal-like ESCC cells (Figs. 3c, d, and Additional file 3 Figure S3B, C). The gene discussed is IVL; the disease is esophageal squamous cell carcinoma.