In agreement with the results using transformed-esophageal cells and ESCC cells, the inhibitory effects of EGFR inhibitors on EGFR phosphorylation were diminished in mesenchymal T-Epi cells, although EGFR phosphorylation was sufficiently suppressed in parental T-Epi cells (Fig. 5c). The gene discussed is EGFR; the disease is esophageal squamous cell carcinoma.