PTHLH and breast cancer: Overall, this suggests that the high circulating calcium levels in African Americans may be due to other factors that alter systemic calcium homeostasis including the release of calcium stimulated osteolytic factors by normal and/or malignant breast tissues [29], and active vitamin D. Unfortunately, PTH and PTHrP were not part of routine clinical tests and only a subset of patient serum chemistries included active vitamin D analysis from the control and BC case cohorts with genotyping data.