To further verify the effects of the polymorphisms (FSHB rs10835638, FSHR rs6165, rs6166, rs1394205) on the risk of male infertility and to quantify potential heterogeneity between various studies, we conducted a case-control study of 255 infertile men and 340 healthy controls from South China, as well as performing a meta-analysis of the results of previous reports and this study. The gene discussed is FSHR; the disease is Infertility.