CRP and Sepsis: The two most frequently used biomarkers are C-reactive protein (CRP) and procalcitonin, although they have limited value as diagnostic and prognostic markers.[6] To date, no single biologic marker has been shown to reliably identify patients who are at risk of developing severe sepsis or septic shock.[7, 8] Several clinical scores have been developed to assess disease severity and predict the outcome of sepsis that included the Acute Physiology and Chronic Health Evaluation (APACHE) score, Sequential Organ Failure Assessment (SOFA) score, and Simplified Acute Physiology Score (SAPS).