IDUA and juvenile open angle glaucoma: Potential immediate opportunities for gene therapy in anterior segment ocular disease may lie in single gene disorders such as mutant myocilin (MYOC) -associated juvenile open angle glaucoma (JOAG) and corneal clouding in lysosomal storage disorders, like alpha-L-iduronidase (IDUA)-associated mucopolysaccharidosis type 1(MPS1).