Analysis of EHBDs and livers 14 days after RRV showed two histological patterns in SMZ/TMP-Cxcr2-/- mice: 1) findings similar to WT mice of obstructed EHBD and expanded portal tracts with inflammation when they were fed regular diet or if they received SMZ/TMP and were symptomatic; and 2) intact EHBD epithelial lining with patent lumen and minimally affected portal tract in SMZ/TMP-Cxcr2-/- mice without jaundice (Fig 1C). Here, CXCR2 is linked to Jaundice.