In turn, Jagged1 on EC reciprocally induces Notch2–Hey1 in lymphoma cells.42 Cao et al. described that TEC convert indolent tumor cells to more aggressive cells with greater tumorigenicity, extranodal invasion, and chemoresistance.42, 43 Moreover, other groups have also demonstrated that the Notch signals in EC are involved in tumor progression and stem cell phenotype.44, 45, 46, 47 Notch activation in EC promotes tumor cell migration and metastasis along with neutrophil infiltration.48 The gene discussed is HEY1; the disease is neoplasm.