In 1971, Judah Folkman proposed that all tumors are angiogenesis dependent.24 Angiogenesis, defined as the growth of new blood vessels from the existing vasculature, is activated in response to the requirement for oxygen and nutrients.25 VEGF (known as vascular permeability factor) is one of the major molecules released from tumor cells to induce angiogenesis. The gene discussed is VEGFA; the disease is neoplasm.