CAF promoted tumorigenesis of tumor cells when cocultured with tumor cells, but not when cocultured with normal fibroblasts.9, 10 CAF activate the invasiveness of tumor cells with the production of MMP.11, 12, 13 CAF produce proinflammatory factors that activate NF‐κB signaling to promote tumor progression.14 Several recent studies have indicated that CAF remodel the tumor microenvironment and regulate tumor progression using their active secretome.7 Here, NFKB1 is linked to neoplasm.