Slit2, which is negatively regulated by the endothelial EphA2 receptor, is one of the tumor suppressive angiocrine factors.49 The authors described that EphA2 represses Slit2 expression in EC to facilitate angiocrine‐mediated tumor invasion by blocking tumor suppressive signals.49 Such juxtacrine signals between EC and adjacent tumor cells could induce protumorigenic characteristics with increased expression of tumor‐stimulating factors or reduced expression of tumor‐suppressive factors. The gene discussed is SLIT2; the disease is neoplasm.