ALK and non-small cell lung carcinoma: Gruber et al. [14] also found full-length ALK transcript expression in 1.1% of NSCLC tumors but none of their patients were treated with ALK inhibitors; of note, similar to our cases, the full-length ALK-positive tumors reported by Gruber and co-workers expressed little or no ALK protein (0 or 1+) on IHC.