TP53 and colorectal cancer: YB‐1 binds CCAAT elements (Y‐box) in the promoter region of MD1 and nuclear levels of YB‐1 correlate with expression of P glycoprotein.101 Reduction of YB‐1 in colorectal cancer cell lines causes induction of p53‐dependent cell death and TP53 levels rise after YB‐1 repression.