YB‐1 binds CCAAT elements (Y‐box) in the promoter region of MD1 and nuclear levels of YB‐1 correlate with expression of P glycoprotein.101 Reduction of YB‐1 in colorectal cancer cell lines causes induction of p53‐dependent cell death and TP53 levels rise after YB‐1 repression. This evidence concerns the gene YBX1 and colorectal cancer.