These include members of the disintegrin and metalloproteinase family, ADAM9 (Peduto et al., 2005; Fritzsche et al., 2008), ADAM12 (Peduto et al., 2006) and ADAM15 (Lucas and Day, 2009) as well as membrane associated serine proteases implicated in PCa, such as type II transmembrane serine proteases (TTSPs) (Webb et al., 2011) or the GPI‐anchored prostasin (Chen et al., 2004). The gene discussed is PRSS8; the disease is posterior cortical atrophy.