TMEFF2, a type I transmembrane protein with two follistatin and epidermal growth factor (EGF) domains, is expressed selectively in the adult brain and prostate (Horie et al., 2000; Liang et al., 2000), with elevated TMEFF2 expression in prostate cancer (PCa) cell lines and clinical samples (Glynne‐Jones et al., 2001; Gery et al., 2002; Afar et al., 2004). Here, EGF is linked to Familial prostate cancer.