At the same time, Couthouis et al. (2011) had searched specifically within the C-terminal zinc finger and RGG domains of TAF15 (not the entire gene) in 735 individuals diagnosed with ALS and discovered several mutations in patients with familial ALS but not in healthy individuals: M368T, G391E, R408C, and G473E (Fig. 1). Here, TAF15 is linked to amyotrophic lateral sclerosis.