The clinical factors associated with shorter survival include age older than 75 years, male gender, primary location on the lips, and tumor diameter greater than 2 cm.25 This corresponds with the histopathologic features of tumor extension beyond the dermis (tumor thickness), positive resection margins, and a high mitosis rate.25,26 In addition, immunosuppression and vitamin D deficiency have a negative correlation with survival.27,28 The effect of T cell infiltration and PD-L1 status has not been confirmed to date, but there may be positive correlations with an improved survival rate.29 Here, CD274 is linked to neoplasm.