Following a missense mutation (CCA→ GCA), Proline is substituted to Alanine at codon 12 exon B and it can affect transcriptional activity of PPAR-γ2 gene.21 Some previous studies have indicated effective roles for Pro12Ala genotype in response to dietary interventions for obesity management.22,23. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.