PPARG and obesity due to melanocortin 4 receptor deficiency: Obesity is a multi-factorial health problem which results from the interaction among metabolic, physiological, social, behavioural, and genetic factors.10 Proliferator-activated receptor gamma-2 (PPAR-γ2) has been considered as a candidate gene for obesity phenotype and its complications.18 PPAR-γ gene, a type II nuclear receptor located on chromosome 3p-25 in humans.