They suggested that positive effects of licorice may be due to its strong taste that can decrease food intake and appetite.17 Possible anti-obesity mechanisms for licorice are as follows: 1) regulation of lipid metabolism and lipolysis through effects on gene expression in fatty acid synthesis pathways and increase of fatty acid oxidation5,2) activation of PPAR-γ gene5,3) reduction in appetite due to strong taste 17 and 4) reduction in fat intestinal absorption.6 The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.