TBX5 and coronary artery disorder: The combination of these two independent studies showed a 1.83-fold increased CHD risk when the dominant model is used for TBX5 rs6489956 (P=3.62×10−8) in a total number of 1 177 CHDs patients and 990 controls (Table 1), with an adjusted OR of 1.94 (95% CI=1.52–2.47, P=8.21×10−8) and 2.31 (95% CI=1.01–5.30, P=0.033) for the CT and TT genotypes, respectively.