The purpose of this study was to investigate expression of three alarmins in human supraspinatus tendons that have been implicated in sustaining chronic inflammation in diseased musculoskeletal tissues: 1) S100A9 2) high-mobility group box 1 (HMGB1) and 3) interleukin-33 (IL-33).18 Although there is a growing list of alarmins in the literature, these are the most thoroughly studied and implicated in other musculoskeletal diseases yet have not been investigated in tendinopathy. The gene discussed is HMGB1; the disease is musculoskeletal system disorder.