Stranjalis, et al. evaluated the connection between serial serum S100B protein measurements and post-craniotomy clinical worsening in patients with meningioma surgery.   44  S100B serum condensation in patients diagnosed with glioma have been surveyed in some studies.46 ,47 Gartner, et al.48 showed elevated plasma levels of S100B in the peripheral blood of two of three patients, at 11 and 13 months prior to the detection of a malignant glioma. This evidence concerns the gene S100B and central nervous system cancer.