CYCS and chronic myelogenous leukemia, BCR-ABL1 positive: According Sreekanth et al. [49], pitaya extract compounds (betacyanin and anthocyanin) and pigments act on K562 cells that lead to human chronic myeloid leukemia altering the integrity of the mitochondrial membrane, leading to leakage of cytochrome c, caspase activation, and nuclear disintegration.