In addition, some gene fusions can lead to activation of oncogenes (for example, R-spondin fusion proteins active the oncogenic Wnt/β-catenin signaling in colon cancer) or inactivation of tumor suppressor genes (for example, LACTB2-NCOA2 disrupts NCOA2 in colorectal cancer)6, 7. The gene discussed is NCOA2; the disease is colorectal cancer.