In conclusion, the aberrant up-regulation of miR-125a-5p in Treg cells of patients with T1D when residing in the pancreatic draining lymph nodes, possibly due to local inflammation or disease-specific signals, leads to reduced CCR2 expression and this may impede the pancreas-specific migration of Treg cells, thus depriving this organ of immune cells key for maintenance of peripheral tolerance. This evidence concerns the gene CCR2 and type 1 diabetes mellitus.