Among analyzed miR-125a-5p target genes, CCR2 was taken into consideration for further experiments: i) because CCR2 is the receptor of CCL2 (MCP1) previously suggested to be associated to T1D pathogenesis; ii) CCR2 expression in Treg cells modulates their function by modifying their capacity to migrate to inflamed sites and to suppress immune cell activity, thus potentially contributing to impaired Treg cells function in PLN of T1D patients. The gene discussed is CCR2; the disease is type 1 diabetes mellitus.