Our present results implied that the combination of serum tPA, PAI-1, BDNF, proBDNF, TrkB and p75NTR in tPA-BDNF pathway yield high differential power between MDD and BD (AUC = 0.893, sensitivity = 0.895 and specificity = 0.800). This evidence concerns the gene NTRK2 and major depressive disorder.