However, the combination of tPA, PAI-1, BDNF, proBDNF, TrkB and p75NTR yield an excellent diagnostic value between SZ and HCs (AUC = 0.935, sensitivity = 0.960 and specificity = 0.769) and SZ and PD (AUC = 0.933, sensitivity = 0.750 and specificity = 0.962), and a fair differential efficacy between SZ and MDD (AUC = 0.798, sensitivity = 0.720 and specificity = 0.769), and SZ and BM (AUC = 0.745, sensitivity = 0.955 and specificity = 0.462), and SZ and BD (AUC = 0.721, sensitivity = 0.842 and specificity = 0.654). The gene discussed is SERPINE1; the disease is major depressive disorder.