SPP1 and myocardial infarction: The IL-4 administration after the onset of MI was able to increase CD206+F4/80+ M2-like macrophages, which highly expressed a range of anti-inflammatory and tissue repair-related genes, including Il10, Il1rn, Hif1a, Vegfa, Igf1, Cxcl12, Spp1 and Tgfb, in the damaged myocardium.