Corresponding to this observation in vitro, expression of Igf1 and Hif1a, in addition to Mrc1 (Cd206), in the post-MI myocardial tissue (including the infarct and border areas) was significantly upregulated in the IL-4c group, compared to the PBS group (Fig. 2b). The gene discussed is HIF1A; the disease is myocardial infarction.