Thus, in this study, we used the CUMS model to investigate the antidepressant-like activity and cognitive impairment effects of SCE, moreover, the BDNF/TrkB/ERK/CREB and PI3K/AKT/GSK-3β signaling pathways were determined to illustrate the action mechanism of SCE. The gene discussed is GSK3B; the disease is Cognitive impairment.