Blazquez-Medela et al. (2012) studied relationship between serum TNFRSF11B (Osteoprotegerin (OPG)) and vascular alteration in associated pathologies and its levels were found to be higher in diabetic, hypertensive with retinopathy and cardiovascular risk patients and therefore associated with cardiovascular risk in diabetes and hypertension patients44. This evidence concerns the gene TNFRSF11B and diabetes mellitus.