Yamaji et al. (2008) determined whether TEM7 (PLXDC1) is associated with formation of fibrovascular membranes (FVMs) further responsible to cause proliferative diabetic retinopathy (PDR) and observed significant role of TEM7 in the proliferation and maintenance of neovascular endothelial cells in FVMs and also could be molecular target for new diagnostic of PDR68. This evidence concerns the gene PLXDC1 and proliferative diabetic retinopathy.