59 genes were reportedly being investigated in multiple years for their role in atherosclerosis, for example the genes ABCA1, PON1, MTHFR, PLTP, PPAR, TNFRSF11B (OPG), FABP4, and IL18 are being studied for several years since 1997 with varying emphasis. The gene discussed is MTHFR; the disease is atherosclerosis.