We observed 19 of these genes differentially expressed in T2DM patients with Padj <=0.05, namely, ADCYAP1, ALDH2, APPL1, CAT, CDKAL1, DCXR, ERBB3, FGF21, HDAC4, HLA-DQA1, NFE2L2, NGF, PECAM1, PROC, RBP4, SIRT6, SYVN1, TIMMP4 and TRPV4. None of the genes had fold change (FC) either >2 or <0.5. The gene discussed is APPL1; the disease is type 2 diabetes mellitus.