Nearly 48.44% of genes (78 genes) were studied in multiple years including ACE, AGER, ADIPOQ, SERPINF1 and SIRT1. Pradeepa et al. (2015) recently proposed to assess the association of ADIPOQ (adiponectin) and microvascular complications of diabetes and observed that serum adiponectin levels were associated with diabetes associated complications and also with severity of retinopathy69. Here, ACE is linked to diabetes mellitus.