In the present study, we found that the UCHL1-mediated activation of HIF-1 through the deubiquitination of HIF-1α protein induced the antioxidant and radioresistant properties of cancer cells by producing an antioxidant, GSH, through the so-called carbohydrate metabolic reprogramming and subsequent activation of the pentose phosphate pathway. Here, HIF1A is linked to cancer.